MN551-4: Evaluate the presence and effects of alteration in the homeostatic state secondary to gender, genetic, ethnic and temporal variables

Select one of the case studies below, and include in your discussion an evaluation of the presence and effects of alteration in the homeostatic state secondary to gender, genetic, ethnic, and temporal variables.

Requirements:

1. Make sure all of the topics in the case study have been addressed.
2. Cite at least three sources; journal articles, textbooks or evidenced-based websites to support the content.
3. All sources must be within 5 years.
4. Do not use .com, Wikipedia, or up-to-date, etc., for your sources.

Case Study 1

Structure and Function of the Respiratory System

Brad is 45 years old and has been working as a coal cutter in a mine for the last 25 years. He likes the job because it pays well and the same mine had employed his father. Like many of his colleagues, Brad has had problems with a chronic cough. He has avoided his annual checkups for fear that he will be told he has “black lung,” or coal worker’s pneumoconiosis. The disease causes fibrosis, decreased diffusing capacity, and permanent small airway dilation. In later stages, pulmonary capillaries, alveoli, and airways are destroyed.

1. How can the disease described above create a mismatch between ventilation and perfusion? Use your understanding of alveolar dead space and physiologic shunt to explain your answer.
2. Individuals with chronic obstructive pulmonary disease have more difficulty exhaling than inhaling. Why is this so?
3. In general terms, what mechanisms in lung disease can affect diffusing capacity across alveolar membranes? Use the Fick law to explain your answer.
5. Assignment Requirements:
6. Before finalizing your work, you should:
   • Ensure you have written at least four double-spaced pages.
   • be sure to read the Assignment description carefully (as displayed above);
   • consult the Grading Rubric (under the Course Resources) to make sure you have included everything necessary; and
   • utilize spelling and grammar check to minimize errors.
   • follow the conventions of Standard American English (correct grammar, punctuation, etc.);
   • be well ordered, logical, and unified, as well as original and insightful;
   • display superior content, organization, style, and mechanics; and
   • use APA 6th Edition format.